Division Heads: Dr. Ruff, Dr. Jakob, Dr. Vojcic, Dr. Zhu, Dr. Bococla

Within the AG Schwaneberg, in five divisions a joint research agenda is pursued to discover fundamental protein engineering principles and to apply tailored biocatalysts in industrial applications. The scientific competence is built on an array of in-house developed methods and technology platforms for directed evolution which comprises diversity generation methods in the division Molecular Bioeconomy, high throughput screening systems in the division Hybrid Catalysis & High Throughput Screening, and tools to analyze and design proteins in the division Computational Biology that will ultimately lead to tailored-biocatalysts for significant applications in industry. Within two application subgroups, namely the divisions Next Generation Biocatalysis and Biohybrid Systems, interdisciplinary projects utilize protein engineering to design novel applications for industrial applications and material sciences.

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Hybrid catalysis & High-throughput screening

Division Hybrid Catalysis & High Troughput Screening

We are developing artificial metalloenzymes and robust high throughput screening platforms for directed enzyme evolution.

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Molecular Bioeconomy

Division Molecular Bioeconomy

Our methods for diversity generation are used to tailor enzymes for an integrated and sustainable bioeconomy

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Biohybrid Systems at DWI

Division Biohybrid systems

We engineer proteins, enzymes and peptides to develop biohybrid materials with tailor-made properties and functionalities.

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Next Generation Biocatalysis

Junior Research group Next Generation Biocatalysis

We develop new enzymatic reactions or reaction cascades, methods and technologies to overcome the limitations of aqueous biotransformations.

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Computational Biology

Division Computational Biology

We focus on the analysis and prediction of protein variant properties & characteristics by applying computational methods.

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Publications and Patents

Cover of highlighted publications

We are experts in protein engineering with a focus on directed evolution approaches and semirational or rational design. Our research includes empirical and computational method development, and the application of the latter to ultimately generate enzyme variants with tailored characteristics. Computational methods further serve to solve structure/function relationships of targeted enzymes. The research output of the group is reflected by over 180 peer-reviewed articles and over 20 filed patents.

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More than 26 currently running projects funded by BMBF, BioSc, DFG, BMWI, DBU, EU, as well as direkt F&E coorperation.

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RWTH Alumni

„Let's keep in touch“.

Have a look for our fomer PhDs, PostDocs, and technical assistants.


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Recent Graduates

Recent Graduates

Congratulations to our recently graduated coworkers.

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